Ovarian Rejuvenation
Rejuvenating the ovaries to improve their egg-producing capacity is known as Ovarian Rejuvenation.
At Sarkar Hospital, Agra, we understand that healthy ovarian function is one of the most crucial factors in IVF success.
Better ovarian health means:
More healthy eggs
Higher chances of creating good-quality embryos
Greater opportunity for embryo selection
And the possibility of freezing extra embryos for future use
Unfortunately, some women experience a decline in ovarian function earlier than expected. Others may plan pregnancy later in life, when a natural reduction in egg reserve occurs. In some cases, women even wish to conceive using their own eggs after menopause — when the ovaries have already stopped producing eggs.
For such patients, Ovarian Rejuvenation offers new hope.
It is particularly beneficial for women with:
Very low AMH (Anti-Müllerian Hormone)
High FSH (Follicle-Stimulating Hormone)
Poor response in previous IVF cycles
Traditionally, doctors have tried to stimulate the ovaries aggressively using high doses of fertility medications to retrieve more eggs in one cycle. However, this approach often increases the cost and discomfort while still yielding few eggs.
PRP – Platelet Rich Plasma therapy
Platelets are naturally rich in cytokines and growth-promoting factors that play a key role in tissue repair and regeneration. By activating and enriching these platelets, we create a potent concentrate known as PRP, which can help rejuvenate the ovaries and enhance their egg-producing ability.
How It Works
A small sample of the patient’s own blood is collected.
The blood is processed in our in-house laboratory to separate and concentrate the platelets.
The prepared PRP is then enriched and activated to boost its regenerative potential.
Finally, the PRP is injected into both ovaries under ultrasound guidance using a very fine needle.
Advantages
Prepared entirely from the patient’s own blood — no external drugs or materials.
Simple, minimally invasive, and relatively inexpensive.
Can improve ovarian response naturally or in IVF cycles.
Long-lasting benefits that may extend beyond a single treatment cycle.
Has helped many women achieve pregnancy — even naturally — despite low chances earlier.
Disadvantages & Limitations
Results vary between patients.
It is not a guaranteed or permanent solution.
The positive effects may reduce gradually over time.
Stem cell Therapy
Stem cells are special cells from the patient’s own body that have the ability to transform into various types of body cells. They offer great potential for regenerative medicine, including the rejuvenation of ovarian tissue.
How It Works
Stem cells are usually derived from bone marrow, collected from the hip bone under local anesthesia or light sedation.
The extracted stem cells are processed and then injected into the ovaries to help restore ovarian activity and egg production.
Advantages
Uses the patient’s own cells, minimizing risks of infection or immune rejection.
Safe and effective in several medical and fertility treatments.
Offers regenerative potential for damaged ovarian tissues.
Has shown promising results in women with low ovarian reserve.
Disadvantages & Limitations
More invasive than PRP; requires minor surgical intervention.
More expensive compared to PRP therapy.
Clinical results vary — not all patients show improvement.
Not yet proven to be consistently superior to PRP in all cases.
Success rate of stem cell therapy in ovarian rejuvenation procedure
At Sarkar Hospital, Agra, we continuously stay updated with the latest advances in fertility science to offer the most effective and ethical treatments.
The success rate of Stem Cell Therapy for Ovarian Rejuvenation varies from patient to patient. While several studies have shown encouraging outcomes — such as improved ovarian function, increased hormone levels, and even spontaneous pregnancies — the therapy is still considered experimental and under ongoing medical research.
Results can depend on multiple factors, including:
Age of the patient
Baseline ovarian reserve (AMH and FSH levels)
Underlying medical or hormonal conditions
Response of ovarian tissue to regenerative therapy
Many women experience improved ovarian responsiveness and better outcomes in IVF cycles after stem cell treatment, but it is important to understand that results cannot be guaranteed and may vary significantly between individuals.
Our fertility experts at Sarkar Hospital guide each patient personally, helping them understand both the potential benefits and limitations of the treatment before proceeding.
Step-by-Step Process of Ovarian Rejuvenation Therapy
1. Initial Consultation and Assessment
Your journey begins with a detailed consultation with our fertility specialist.
We review your medical history, menstrual pattern, and previous fertility treatments.
Hormonal tests such as Anti-Müllerian Hormone (AMH) and Follicle Stimulating Hormone (FSH) are conducted to evaluate ovarian reserve.
An ultrasound scan helps assess the size and condition of your ovaries and follicles.
2. Blood Collection and PRP Preparation
If you are undergoing the PRP (Platelet-Rich Plasma) method, a small amount of your blood is collected.
The sample is processed in a centrifuge to separate platelets and growth factors.
These growth factors are essential for cell repair and regeneration, making PRP a powerful tool to stimulate ovarian activity.
3. Preparation for PRP Injection
Before the injection, the patient is prepared in a setting similar to an IVF egg retrieval procedure.
Local anesthesia or mild sedation is administered to ensure comfort.
The process is quick, minimally invasive, and performed under sterile conditions.
4. Injection of PRP into the Ovaries
Using ultrasound guidance, the prepared PRP is gently injected into both ovaries with a fine needle.
The growth factors in PRP may help revitalize dormant ovarian tissues and promote new follicle growth.
Patients can typically return home the same day after a short recovery period.
5. Post-Treatment Monitoring
In the weeks following the procedure:
Blood tests are performed to track hormone changes and assess ovarian response.
Ultrasound scans are used to monitor follicle development.
This helps evaluate how well the ovaries are responding to the therapy.
6. Follow-Up and Fertility Treatment
If the treatment improves ovarian function and egg production, our fertility experts will help plan the next steps:
In Vitro Fertilization (IVF) or Intrauterine Insemination (IUI) may be initiated, depending on your goals and response.
A personalized fertility plan is created to maximize your chances of conception.
7. Possible Additional Treatments
In some cases, patients may benefit from a second round of PRP injections to further enhance ovarian activity.
Your doctor will advise this based on your individual progress and hormone levels.
8. Success Evaluation
Success is measured through:
Improved AMH and FSH levels
Increased follicle count on ultrasound
Enhanced ovarian responsiveness during stimulation
If pregnancy is achieved — naturally or through assisted reproductive techniques — our team provides continuous monitoring to ensure the best possible outcome.
Drug therapy
1. Androgen Substitutes
The egg development cycle takes approximately three months, and during the initial two months, the process is largely influenced by androgens — hormones commonly known as “male hormones,” but equally vital for female egg development.
Various medications and supplements have been tried to boost androgen activity, though scientific studies show limited and inconsistent results.
One such therapy includes the application of testosterone gel, which must only be used under strict medical supervision.
The more common supplement used is DHEA (Dehydroepiandrosterone).
2. DHEA (Dehydroepiandrosterone)
DHEA is a naturally occurring hormone produced by the adrenal glands and is also present in certain foods.
It is typically prescribed for 3 to 6 months to increase androgen levels within the ovaries.
The goal is to improve egg number and quality, especially in women with low ovarian reserve.
However, in our clinical experience, DHEA offers only marginal benefits. Delaying definitive fertility treatments such as IVF while waiting for improvement from DHEA may reduce ovarian reserve further and lower the overall chances of success.
3. Nutritional Supplements
Certain vitamins and antioxidants are believed to support ovarian health by improving cellular energy and reducing oxidative stress.
Common supplements include:
Coenzyme Q10 (Ubiquinone/Ubiquinol)
Vitamin D
Folic Acid
Other antioxidant-rich nutrients
While these supplements may have general health benefits, the percentage of patients who show significant improvement in fertility parameters from nutritional therapy alone is quite low.
4. Our Expert Opinion
At Sarkar Hospital, Agra, we recommend not relying solely on medical or nutritional therapies for ovarian rejuvenation.
The major drawback is the time lost waiting for improvement that may never occur — time that is crucial for preserving fertility.
Our approach focuses on integrating ovarian rejuvenation techniques like PRP or Stem Cell Therapy along with timely IVF treatment to maximize success rates.
The key is to act early, avoid unnecessary delays, and follow a personalized, evidence-based fertility plan under expert guidance.