{"id":589,"date":"2025-10-25T10:11:18","date_gmt":"2025-10-25T10:11:18","guid":{"rendered":"https:\/\/sarkarhospital.in\/?page_id=589"},"modified":"2025-12-13T08:17:47","modified_gmt":"2025-12-13T08:17:47","slug":"preimplantation-genetics","status":"publish","type":"page","link":"https:\/\/sarkarhospital.in\/?page_id=589","title":{"rendered":"PREIMPLANTATION GENETICS"},"content":{"rendered":"\t\t
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Pre - Implantation Genetic Testing - PGT<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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Advanced Genetic Screening for Healthier Embryos and Improved IVF Success<\/em><\/h3>

With the advancement of In Vitro Fertilization (IVF)<\/strong> and genetic testing technologies<\/strong>, it is now possible to perform genetic diagnosis at the embryo stage<\/strong>. This allows fertility specialists to identify genetically normal embryos<\/strong> before pregnancy begins, helping improve success rates and reduce the risk of genetic disorders.<\/p>

Pre-Implantation Genetic Testing (PGT)<\/strong> involves examining embryos before implantation<\/strong> in the uterus \u2014 ensuring only healthy embryos are selected for transfer, resulting in safer and more successful pregnancies.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Why Pre-Implantation Genetic Testing \u2013 PGT PGS PGD<\/h3>\t\t\t\t<\/div>\n\t\t\t\t
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1. PGT-A (Pre-implantation Genetic Testing for Aneuploidy)<\/strong><\/h2>

Also known as PGS \u2013 Pre-implantation Genetic Screening<\/em><\/p>

PGT-A screens embryos for chromosomal abnormalities<\/strong> (aneuploidy), which are one of the major causes of IVF failure and miscarriage<\/strong>.
By identifying embryos with the correct number of chromosomes, PGT-A allows selection of genetically normal embryos<\/strong> for transfer.<\/p>

Benefits of PGT-A:<\/strong><\/h3>

  • Improves implantation rates<\/strong> and reduces the risk of miscarriage<\/p><\/li>

  • Helps prevent Down\u2019s syndrome<\/strong> and other chromosomal disorders associated with advanced maternal age<\/p><\/li>

  • Recommended for:<\/p>

    • Women of advanced age<\/strong><\/p><\/li>

    • Recurrent IVF failures<\/strong><\/p><\/li>

    • Recurrent pregnancy losses<\/strong><\/p><\/li>

    • Severely abnormal sperm parameters<\/strong><\/p><\/li><\/ul><\/li><\/ul>

      PGT-A offers the fastest route to IVF success<\/strong>, minimizing the time to pregnancy<\/strong> by transferring embryos most likely to result in a healthy pregnancy.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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      2. PGT-M (Pre-implantation Genetic Testing for Monogenic Disorders)<\/strong><\/h2>

      Also known as PGD \u2013 Pre-implantation Genetic Diagnosis<\/em><\/p>

      PGT-M is used when one or both parents are carriers of a known genetic mutation<\/strong>. This testing helps prevent the transmission of specific hereditary diseases<\/strong> to the child.<\/p>

      It focuses on monogenic (single-gene) disorders<\/strong>, which occur due to defects in a single gene.<\/p>

      Conditions Detectable Through PGT-M Include:<\/strong><\/h3>

      • Beta-Thalassemia<\/strong><\/p><\/li>

      • Sickle Cell Disease<\/strong><\/p><\/li>

      • Spinal Muscular Atrophy (SMA Type 1)<\/strong><\/p><\/li>

      • Haemophilia<\/strong><\/p><\/li>

      • Duchenne Muscular Dystrophy (DMD)<\/strong><\/p><\/li><\/ul>

        If the defective gene responsible for an inherited condition is known, PGT-M can prevent its transmission<\/strong> \u2014 allowing couples to have genetically healthy children.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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        3. PGT-SR (Pre-implantation Genetic Testing for Structural Rearrangements)<\/strong><\/h2>

        PGT-SR is performed when either partner carries chromosomal structural rearrangements<\/strong> such as translocations or inversions.
        These rearrangements can increase the risk of genetic abnormalities in embryos<\/strong>, leading to failed implantations or miscarriages.<\/p>

        Benefits of PGT-SR:<\/strong><\/h3>

        • Detects and excludes embryos with structural chromosomal abnormalities<\/strong><\/p><\/li>

        • Enhances IVF success rates<\/strong><\/p><\/li>

        • Reduces the risk of miscarriage<\/strong> and genetic disorders in the baby<\/p><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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          HLA matching<\/h4>\t\t\t\t<\/div>\n\t\t\t\t
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          Some genetic conditions, such as Thalassemia<\/strong>, can only be permanently cured<\/strong> through a bone marrow transplant<\/strong> or similar advanced treatments.
          For a successful bone marrow transplant, a Human Leukocyte Antigen (HLA)\u2013matched donor<\/strong> is required.<\/p>

          Finding a perfectly matched donor is extremely difficult, even among family members. However, for couples who already have an affected child<\/strong>, genetic testing and IVF<\/strong> can offer a unique and life-saving solution \u2014 the possibility of conceiving another child who is:<\/p>

          • Free from the genetic disease<\/strong>, and<\/p><\/li>

          • HLA-matched<\/strong> with the affected sibling<\/p><\/li><\/ul>

            Such a child can serve as a potential bone marrow donor<\/strong>, giving the affected sibling a chance for complete recovery.<\/p>

            At Sarkar Hospital, Agra<\/strong>, our advanced Pre-Implantation Genetic Testing (PGT)<\/strong> techniques make this possible \u2014 combining compassion, precision, and cutting-edge science to give hope to families affected by inherited conditions.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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            Process of PGT<\/h4>\t\t\t\t<\/div>\n\t\t\t\t
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            The PGT process<\/strong> follows the standard IVF procedure<\/strong>, with an additional step for genetic testing of embryos<\/strong> before transfer.<\/p>

            Step-by-Step Overview:<\/strong><\/h3>

            1. IVF Procedure:<\/strong>
              Eggs are retrieved from the ovaries and fertilized with sperm in the laboratory to form embryos.<\/p><\/li>

            2. Embryo Development:<\/strong>
              The embryos are cultured and grown to the Day 3 (cleavage stage)<\/strong> or Day 5 (blastocyst stage)<\/strong>.<\/p><\/li>

            3. Embryo Biopsy:<\/strong>
              Using a precise laser<\/strong>, a tiny opening is made in the outer layer (zona pellucida) of the embryo.
              Through this opening, a micropipette<\/strong> gently removes one or a few cells for testing.<\/p><\/li>

            4. Genetic Analysis:<\/strong>
              The collected cells are sent for genetic and chromosomal testing<\/strong> \u2014 to identify healthy, disease-free, and\/or HLA-matched embryos.<\/p><\/li>

            5. Embryo Preservation and Transfer:<\/strong>
              The tested embryos are safely cryopreserved (frozen)<\/strong> until results are available.
              Once a healthy and compatible embryo is identified, it is selected for embryo transfer<\/strong> into the mother\u2019s uterus.<\/p><\/li><\/ol>

              Note:<\/strong> At this early stage, embryos are totipotent<\/strong> \u2014 meaning that removing a few cells does not harm<\/strong> the embryo or affect its ability to develop normally.<\/p><\/blockquote>

              PGT and HLA Matching at Sarkar Hospital<\/strong><\/h3>

              At Sarkar Hospital, Agra<\/strong>, we offer advanced PGT services including HLA matching<\/strong>, PGT-A<\/strong>, PGT-M<\/strong>, and PGT-SR<\/strong>.
              Our team of fertility specialists, embryologists, and genetic experts work together to:<\/p>

              • Identify healthy, genetically normal embryos<\/strong><\/p><\/li>

              • Enable disease-free conceptions<\/strong><\/p><\/li>

              • Offer hope to families affected by inherited blood disorders like Thalassemia<\/strong><\/p><\/li>

              • Support HLA-compatible sibling conception<\/strong> for life-saving transplants<\/p><\/li><\/ul>

                With precision technology and compassionate care<\/strong>, Sarkar Hospital helps families achieve the dual goal of building a healthy family<\/strong> and saving an affected child\u2019s life<\/strong>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

                Pre – Implantation Genetic Testing – PGT Advanced Genetic Screening for Healthier Embryos and Improved IVF Success With the advancement […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_joinchat":[],"footnotes":""},"class_list":["post-589","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sarkarhospital.in\/index.php?rest_route=\/wp\/v2\/pages\/589","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sarkarhospital.in\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sarkarhospital.in\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sarkarhospital.in\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sarkarhospital.in\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=589"}],"version-history":[{"count":8,"href":"https:\/\/sarkarhospital.in\/index.php?rest_route=\/wp\/v2\/pages\/589\/revisions"}],"predecessor-version":[{"id":1398,"href":"https:\/\/sarkarhospital.in\/index.php?rest_route=\/wp\/v2\/pages\/589\/revisions\/1398"}],"wp:attachment":[{"href":"https:\/\/sarkarhospital.in\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=589"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}