IVF failure
Couples undergoing IVF at Sarkar Hospital, Agra, have very good chances of conceiving in the first attempt as well as in subsequent attempts. IVF offers much higher success rates compared to other fertility treatments for the same couple. However, it is important to understand that, like any medical procedure, there is always a possibility of failure.
IVF success depends on both patient factors and clinic expertise.
At Sarkar Hospital, Agra, our IVF labs are designed to provide the most advanced development conditions for embryos. All our IVF labs are Class 1000 labs, ensuring a highly controlled and contamination-free culture environment. We use the latest-generation fertilization equipment and advanced culture incubators to provide the best possible care for eggs, embryos, and blastocysts. (Know more about our infrastructure.)
With years of experience in handling complex fertility cases, Sarkar Hospital gives hope where it may seem lost. Our specialists always create highly individualized, personalized, and optimized ovarian stimulation protocols, which can make a significant difference in IVF outcomes. (Click here to know why Sarkar Hospital is different.)
Sarkar Hospital’s Approach to IVF Failure
At Sarkar Hospital, Agra, we follow a systematic and scientific approach to understanding and treating IVF failures. The most important step is a detailed and meticulous analysis of the previous IVF cycle.
Our expert team carefully breaks down the cycle into different stages and examines each aspect thoroughly. By identifying the smallest details, we are able to pinpoint possible causes and use those findings to fine-tune and personalize future treatment plans.
This careful evaluation and continuous improvement give our patients renewed hope and a better chance of success in their next attempt.
Stimulation
The number and quality of eggs (oocytes) collected during the cycle are carefully analyzed. Based on this, our specialists decide the most suitable dose and stimulation protocol for each patient. Depending on individual needs, we may recommend:
Long protocol
Short protocol
Microdose flare protocol
Minimal stimulation IVF
For patients with a very low number of oocytes, we also offer advanced options like ovarian rejuvenation therapy and dual stimulation (DuoStim) for better results.
Fertilization
In most cases, about 70% or more mature oocytes fertilize successfully to form embryos. If fertilization is poor, we may advise further tests such as sperm DNA fragmentation testing and, in rare cases, specialized genetic testing.
To improve fertilization outcomes, we use advanced techniques like:
PICSI (Physiological ICSI): Helps select sperm that naturally bind to the egg’s surface, ensuring healthier and higher-quality sperm are chosen.
Spindle View ICSI (PolScope): Assesses egg quality and reduces the risk of damage during fertilization by clearly identifying the site for sperm injection.
Since embryo quality is directly linked to fertilization, these advanced techniques play an important role in improving results for patients who previously had poor fertilization or lower-quality embryos.
Embryo Selection at Sarkar Hospital, Agra
Studies show that about 70% of IVF failures are related to embryo factors, while the remaining 30% are linked to the uterus or other causes. It’s important to understand that not every “good-looking” embryo has the potential to develop into a healthy pregnancy and baby. That’s why careful evaluation and selection of the best-quality embryo is crucial for IVF success.
Blastocyst Culture
An embryo that develops to the 4th–6th day after fertilization is called a blastocyst. Only 30–60% of embryos reach this stage naturally. Culturing embryos to the blastocyst stage allows a natural selection process, helping us identify the strongest embryos with the highest chances of implantation and pregnancy.
PGT (Preimplantation Genetic Testing)
Even embryos that look healthy under the microscope may carry genetic abnormalities. Such embryos often fail to implant or may lead to miscarriage. With PGT, we can screen embryos and select only genetically normal embryos for transfer. This not only maximizes the chance of conception per transfer but also significantly reduces the risk of miscarriage.
Uterine, Pelvic & Maternal Factors in IVF Success
Hysteroscopy
Hysteroscopy allows us to directly examine the uterine cavity and endometrium for conditions that may prevent implantation. Many problems can be diagnosed and corrected in the same procedure. Even when the uterus appears normal, we may perform a minor endometrium activation procedure to further improve implantation chances.
ERA Test (Endometrial Receptivity Array)
The ERA test studies the gene expression profile of the endometrium to identify the most receptive time for embryo transfer. This helps us fine-tune the timing of ET, maximizing the likelihood of successful implantation.
Maternal Factors
Thrombophilias
Thrombophilias are a group of blood clotting disorders that may reduce IVF success and can sometimes cause miscarriage. A simple blood test can detect these conditions. If diagnosed, our specialists prescribe suitable medicines or injections to improve outcomes and reduce risks.
Couple Genetic Study
Chromosomal imbalances in either partner may lead to genetically abnormal embryos. Such embryos often fail to implant or may cause miscarriage. Through a chromosome blood test, we can identify these issues. If detected, PGT (Preimplantation Genetic Testing) helps in selecting healthy embryos for transfer, improving the chances of a healthy pregnancy.
When IVF fails, what’s next?
At Sarkar Hospital, Agra, we believe IVF failure is not the end of the journey—it is a stepping stone toward success. We provide medical, emotional, and social support to help you move forward with confidence.
Infertility Counselling
Counselling provides a safe space to express your feelings and emotions without judgment. With professional guidance, couples can explore coping strategies, manage stress, and support each other better throughout the journey.
IVF Support Groups
Connecting with people who share similar experiences can make you feel less alone. Local and online support groups allow couples to share stories, find inspiration, and gain emotional strength while continuing their fertility journey.
Endometrial Receptivity Assay (ERA)
ERA is an advanced test that examines the gene expression profile of the endometrium to identify the most receptive window for embryo transfer. This helps us choose the perfect day for implantation, improving success rates.
Uterine Evaluation / Hysterosalpingogram (HSG)
A detailed evaluation of the uterus and fallopian tubes helps identify hidden issues. By determining the exact tubal status, this test can reduce the risk of IVF failure by nearly 50%.
Additional IVF Cycles
It’s important to remember that IVF success often requires multiple attempts. A failed cycle does not mean the end—it simply means we gather more information, adjust the approach, and move closer to achieving a successful pregnancy.